1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE
• CAS No.: 553631-05-3
• Molecular Formula: C16H22FNO3
• Molecular Weight: 295.354
• Mol file: 553631-05-3.mol

Synonyms:1-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE;1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE;tert-Butyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate

Chemical Property of 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE

Chemical Property:

• PSA: 49.77000
• LogP: 2.98210

Purity/Quality:

97% ^*data from raw suppliers

1-BOC-4-(4-fluorophenyl)-4-hydroxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE

There total 7 articles about 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane (225916-39-2) → tert-butyl 4-hydroxy-4-(4-fluorophenyl)-1-piperidinecarboxylate (553631-05-3)

Guidance literature:

With C₆₂H₇₄Cl₂N₄Pd₂S₂; potassium carbonate; In toluene; at 120 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1002/cctc.202001464

Reference yield: 86.0%

→ tert-butyl 4-hydroxy-4-(4-fluorophenyl)-1-piperidinecarboxylate (553631-05-3)

Guidance literature:

Reference yield: 82.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane (225916-39-2) → tert-butyl 4-hydroxy-4-(4-fluorophenyl)-1-piperidinecarboxylate (553631-05-3)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c1cc10826c

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

1-Bromo-4-fluorobenzene

4-flourophenylmagnesium bromide

2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Downstream raw materials:

4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride

tert-butyl 4-fluoro-4-(4-fluorophenyl)piperidine-1-carboxylate

4-(4-fluorophenyl)piperidin-4-ol

4-(4-fluorophenyl)-4-(2-pyrrolidin-1-yl-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester