(2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:(2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER
CAS No.:128811-31-4
Molecular Formula:C₁₆H₃₁NO₄Si
Molecular Weight:329.512
Hs Code.:
Mol file:128811-31-4.mol

Synonyms:(2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER;D-1-BOC-O-TBDMS-PYROGLUTAMINOL

Suppliers and Price of (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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American Custom Chemicals Corporation
(2R)-2-[[[(1,1-DIMETHYL ETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 504.71

Total 0 raw suppliers

Chemical Property of (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER

Chemical Property:

PSA：55.84000
LogP:3.87220

Purity/Quality:: (2R)-2-[[[(1,1-DIMETHYL ETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

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Technology Process of (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER

There total 15 articles about (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 128899-30-9,100548-49-0,106191-02-0
(R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one

: 128811-31-4
tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane;
DOI:10.1016/0957-4166(96)00254-6

Reference yield: 69.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1244958-71-1
C₂₀H₃₃NO₅Si

: 128811-31-4
tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; triethylamine; at 20 ℃; for 48h;
DOI:10.1016/j.tetlet.2010.06.001

Reference yield:

: 141293-28-9
N-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyl)oxy]pyrrole

: 128811-31-4
tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / SnCl₄ / diethyl ether / 3 h / -85 °C

2: 92 percent / H₂, AcONa / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature

3: 80percent aq. acetic acid / 8 h / 50 °C

4: aq. NaIO₄, SiO₂ / CH₂Cl₂ / 0.25 h

5: 1.8 g / NaBH₄ / methanol / 2 h / -30 - 0 °C

6: imidazole / CH₂Cl₂ / 18 h

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; hydrogen; sodium acetate; silica gel; tin(IV) chloride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm960400q