N,N,1-Trimethyl-1H-imidazole-2-carboxamide

Base Information

• Chemical Name: N,N,1-Trimethyl-1H-imidazole-2-carboxamide
• CAS No.: 129378-60-5
• Molecular Formula: C7H11N3O
• Molecular Weight: 153.18
• DSSTox Substance ID: DTXSID80434809
• Mol file: 129378-60-5.mol

Synonyms:129378-60-5;N,N,1-Trimethyl-1H-imidazole-2-carboxamide;N,N,1-trimethylimidazole-2-carboxamide;1H-Imidazole-2-carboxamide,N,N,1-trimethyl-(9Cl);1H-Imidazole-2-carboxamide,N,N,1-trimethyl-(9CI);SCHEMBL12501240;DTXSID80434809;AKOS017413640

Chemical Property of N,N,1-Trimethyl-1H-imidazole-2-carboxamide

Chemical Property:

• Boiling Point: 257℃
• Flash Point: 109℃
• PSA: 38.13000
• Density: 1.11
• LogP: 0.12190
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 153.090211983
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

99.0%min ^*data from raw suppliers

N,N,1-trimethyl-1H-Imidazole-2-carboxamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C=CN=C1C(=O)N(C)C

Technology Process of N,N,1-Trimethyl-1H-imidazole-2-carboxamide

There total 3 articles about N,N,1-Trimethyl-1H-imidazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 1-methyl-1H-imidazole-2-carboxylate (62366-53-4) + dimethyl amine (124-40-3) → 1-methyl-N,N-dimethylimidazole-2-carboxamide (129378-60-5)

Guidance literature:

In methanol; water; 1) 0 deg C, 5 h; 2) room temperature, overnight;

Reference yield: 36.0%

1-methyl-1H-imidazole (616-47-7) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 1-methyl-N,N-dimethylimidazole-2-carboxamide (129378-60-5)

Guidance literature:

1-methyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 1h;

DOI:10.1039/c6ob02537d

Reference yield:

1-methyl-1H-imidazole (616-47-7) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 1-methyl-N,N-dimethylimidazole-2-carboxamide (129378-60-5) + bis(N-methylimidazol-2-yl)ketone (62366-40-9)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1) hexane, 2a) Et₂O, -78 deg C, 2.4h, 2b) 0 deg C, 25 min;

upstream raw materials:

1-methyl-1H-imidazole

N,N-Dimethylcarbamoyl chloride

methyl 1-methyl-1H-imidazole-2-carboxylate

dimethyl amine

Downstream raw materials:

5-hydroxydiphenylmethyl-1-methyl-N,N-dimethylimidazole-2-carboxamide