6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE

Base Information

• Chemical Name: 6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE
• CAS No.: 149806-05-3
• Molecular Formula: C8H9BrN2O2
• Molecular Weight: 245.07
• Hs Code.: 2933399090
• Mol file: 149806-05-3.mol

Synonyms:6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE;6-BROMO-N-METHOXY-N-METHYLPYRIDINE-3-CARBOXAMIDE

Chemical Property of 6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE

Chemical Property:

• PSA: 42.43000
• LogP: 1.47750
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-N-methoxy-N-methylnicotinamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE

There total 3 articles about 6-BROMO-N-METHOXY-N-METHYLNICOTINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-bromonicotinic acid (6311-35-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 6-bromo-N-methoxy-N-methylpyridine-3-carboxamide (149806-05-3)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 23 ℃;

DOI:10.1021/jacs.9b10414

Reference yield: 62.0%

6-bromonicotinoyl chloride (740841-42-3) + N,0-dimethylhydroxylamine (1117-97-1) → 6-bromo-N-methoxy-N-methylpyridine-3-carboxamide (149806-05-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

6-bromonicotinic acid (6311-35-9) → 6-bromo-N-methoxy-N-methylpyridine-3-carboxamide (149806-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Reflux

2: triethylamine / dichloromethane / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

upstream raw materials:

6-bromonicotinoyl chloride

N,0-dimethylhydroxylamine

6-bromonicotinic acid

N,O-dimethylhydroxylamine*hydrochloride