3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER
• CAS No.: 143527-74-6
• Molecular Formula: C19H27NO5
• Molecular Weight: 349.427
• Mol file: 143527-74-6.mol

Synonyms:3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER;(4S-trans)-2,2-DiMethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 3-(1,1-DiMethylethyl) 5-Ethyl Ester

Chemical Property of 3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 427.292°C at 760 mmHg
• Flash Point: 212.219°C
• PSA: 65.07000
• Density: 1.11g/cm³
• LogP: 3.60070
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

3-(t-Boc)-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl]formicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER

There total 9 articles about 3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methoxypropene (116-11-0) + (2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine (143527-75-7) → ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate (143527-74-6)

Guidance literature:

With pyridinium p-toluenesulfonate; In toluene; at 80 ℃;

DOI:10.1016/S0040-4039(00)79128-3

Reference yield:

2-Methoxypropene (116-11-0) + sodium hydrogencarbonate (144-55-8) + (2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine (143527-75-7) → ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate (143527-74-6)

Guidance literature:

With toluene-4-sulfonic acid; In toluene;

Reference yield:

(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester (144787-20-2) → ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate (143527-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr

2: 76 percent / NaHCO₃ / CH₂Cl₂ / 20 °C

3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C

With hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;

DOI:10.1016/S0040-4039(00)79128-3

upstream raw materials:

2-Methoxypropene

(2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine

di-tert-butyl dicarbonate

(2R,3S)-3-amino-3-phenyl-2-hydroxypropionic acid ethyl ester

Downstream raw materials:

(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

10-deacetyl-7,10-diTroc-baccatin III

Docetaxel

taxol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143527-74-6 3-(T-BOC)-2,2-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-5-YL]FORMIC ACID ETHYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send