1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Base Information

• Chemical Name: 1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid
• CAS No.: 10561-89-4
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Mol file: 10561-89-4.mol

Synonyms:1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid;1-Methyl-4-oxo-1,4-dihydro-pyridine-3-carbaldehyde;1-Methyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Chemical Property of 1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Chemical Property:

• Melting Point: 245 - 247 °C (ethanol)
• PSA: 59.30000
• LogP: 0.08350

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylicacid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

There total 6 articles about 1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid (10561-89-4)

Guidance literature:

Reference yield: 85.0%

1,4-dihydro-4-oxopyridine-3-carboxylic acid (72676-96-1) + methyl iodide (74-88-4) → 1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid (10561-89-4)

Guidance literature:

1,4-dihydro-4-oxopyridine-3-carboxylic acid; With potassium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 40 ℃; for 1h;

methyl iodide; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b01357

Reference yield:

4-hydroxynicotinic acid (609-70-1) + methyl iodide (74-88-4) → 1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid (10561-89-4)

Guidance literature:

In N,N-dimethyl-formamide; for 2h;

upstream raw materials:

4-hydroxynicotinic acid

methyl iodide

4-Chloropyridine

4-chlorpyridine hydrochloride

Downstream raw materials:

4-(1-(3-ethoxy-4-isopropoxyphenyl)-2-(N'-(1-methyl-4-oxo-1,4-dihydropyridine-3-carbonyl)hydrazino)-2-oxo-ethylamino)-benzamidine trifluoroacetate

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