METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE

Base Information

• Chemical Name: METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE
• CAS No.: 63024-30-6
• Molecular Formula: C16H17NO2
• Molecular Weight: 291.777
• Hs Code.: 2922499990

Synonyms:METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE;(S)-METHYL 2-AMINO-3-(BIPHENYL-4-YL)PROPANOATE HYDROCHLORIDE;Methyl 4-phenyl-L-phenylalanate HCl

Chemical Property of METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE

Chemical Property:

• Vapor Pressure: 2.05E-07mmHg at 25°C
• Boiling Point: 418.8°C at 760 mmHg
• Flash Point: 207.1°C
• PSA: 52.32000
• LogP: 3.89870

Purity/Quality:

99% ^*data from raw suppliers

METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE

There total 3 articles about METHYL-2-(S)-BIPHENYL-2-AMINOPROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid (155760-02-4,170080-13-4) → (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (63024-30-6,169885-19-2)

Guidance literature:

With thionyl chloride; at 0 ℃; for 16h; Reflux;

DOI:10.1002/cmdc.201600218

Reference yield: 94.0%

methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate (137255-86-8) → (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (63024-30-6,169885-19-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 3h; Ambient temperature;

DOI:10.1021/jo00027a066

Reference yield:

methanol (67-56-1) + N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine (119273-61-9,128779-47-5,147923-08-8) → (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (63024-30-6,169885-19-2)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1002/psc.2414

upstream raw materials:

methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate

methanol

(S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid

N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine

Downstream raw materials:

(S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-biphenyl-4-yl-propionic acid methyl ester

(2S)-[(2-biphenyl-4-yl-(1S)-1-methoxycarbonyl-ethylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

3-biphenyl-4-yl-(2S)-[(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester

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