Methyl p-aminophenylcarbamate

Base Information

• Chemical Name: Methyl p-aminophenylcarbamate
• CAS No.: 6465-03-8
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• European Community (EC) Number: 229-280-4
• UNII: HNZ6AYZ6AW
• DSSTox Substance ID: DTXSID6064373
• Nikkaji Number: J108.692H
• Wikidata: Q81991499
• Mol file: 6465-03-8.mol

Synonyms:methyl N-(4-aminophenyl)carbamate;6465-03-8;Methyl p-aminophenylcarbamate;Methyl 4-aminophenylcarbamate;Methyl (4-aminophenyl)carbamate;N-(4-aminophenyl)carbamic acid methyl ester;HNZ6AYZ6AW;N-Carbomethoxy-1,4-benzenediamine;Carbamic acid, (4-aminophenyl)-, methyl ester;Carbamic acid, N-(4-aminophenyl)-, methyl ester;UNII-HNZ6AYZ6AW;SCHEMBL515018;Methyl 4-aminophenylcarbamate #;DTXSID6064373;methylN-(4-aminophenyl)carbamate;EINECS 229-280-4;MFCD00036099;AKOS000204326;AB10046;Carbanilic acid, p-amino-, methyl ester;6465-08-3;CS-0249467;FT-0759597;EN300-43598;Z319610150

Chemical Property of Methyl p-aminophenylcarbamate

Chemical Property:

• Vapor Pressure: 1.31E-10mmHg at 25°C
• Boiling Point: 259.3°Cat760mmHg
• Flash Point: 110.6°C
• PSA: 64.35000
• Density: 1.267g/cm³
• LogP: 2.10130
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 153

Purity/Quality:

99% ^*data from raw suppliers

Methylp-aminophenylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)NC1=CC=C(C=C1)N

Technology Process of Methyl p-aminophenylcarbamate

There total 11 articles about Methyl p-aminophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 4-Nitrophenyl isocyanate (100-28-7) → N-(4-aminophenyl)carbamic acid methyl ester (6465-03-8)

Guidance literature:

With hydrogen; In dichloromethane; at 25 ℃; for 16h;

DOI:10.1080/00397911.2010.494818

Reference yield: 82.0%

methyl N-(4-nitrophenyl)carbamate (1943-87-9) → N-(4-aminophenyl)carbamic acid methyl ester (6465-03-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00730

Reference yield: 78.0%

methyl N-(p-nitrosophenyl)carbamate (222400-05-7) → N-(4-aminophenyl)carbamic acid methyl ester (6465-03-8)

Guidance literature:

With sodium dithionite; In 1,4-dioxane; water; for 0.5h; Heating;

upstream raw materials:

methyl N-(4-nitrophenyl)carbamate

methanol

para-dinitrobenzene

carbon monoxide

Downstream raw materials:

C₁₈H₁₈N₄O₄

C₂₀H₂₀N₄O₄

methyl 4-formamidophenylcarbamate

[4-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)phenyl]carbamic acid methyl ester

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