2-Fluoro-4-(difluoromethyl)pyridine

Base Information

• Chemical Name: 2-Fluoro-4-(difluoromethyl)pyridine
• CAS No.: 84940-51-2
• Molecular Formula: C₆H₄F₃N
• Molecular Weight: 147.1
• Hs Code.: 2933399990
• European Community (EC) Number: 829-669-4
• Mol file: 84940-51-2.mol

Synonyms:2-Fluoro-4-(difluoromethyl)pyridine;84940-51-2;4-(difluoromethyl)-2-fluoropyridine;Pyridine, 4-(difluoromethyl)-2-fluoro- (9CI);MFCD19442245;SCHEMBL12093203;HQURWUNRSQARIS-UHFFFAOYSA-N;AKOS005259973;MS-20239;CS-0246429;Pyridine,4-(difluoromethyl)-2-fluoro-(9ci);EN300-3263800

Chemical Property of 2-Fluoro-4-(difluoromethyl)pyridine

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 147.02958362
• Heavy Atom Count: 10
• Complexity: 107

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-4-(difluoromethyl)pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN=C(C=C1C(F)F)F

Technology Process of 2-Fluoro-4-(difluoromethyl)pyridine

There total 4 articles about 2-Fluoro-4-(difluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoropyridin-4-carboxyaldehyde (131747-69-8) → 4-(difluoromethyl)-2-fluoropyridine (84940-51-2)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; for 1h; Cooling with ice;

Reference yield:

bromodifluoromethane (1511-62-2) + 4-bromo-2-fluoropyridine (128071-98-7) → 4-(difluoromethyl)-2-fluoropyridine (84940-51-2)

Guidance literature:

4-bromo-2-fluoropyridine; With 2,6-dimethylpyridine; tris-(trimethylsilyl)silane; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,2-dimethoxyethane; for 0.25h; Inert atmosphere;

bromodifluoromethane; In 1,2-dimethoxyethane; at 30 ℃; for 18h; Sealed tube; Irradiation; Inert atmosphere;

DOI:10.1002/anie.201807629

Reference yield:

(2-fluoropyridin-4-yl)methanol (131747-60-9) → 4-(difluoromethyl)-2-fluoropyridine (84940-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 1 h / Cooling with ice

With manganese(IV) oxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane;

upstream raw materials:

picoline

2-fluoropyridin-4-carboxyaldehyde

(2-fluoropyridin-4-yl)methanol

bromodifluoromethane

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