6-METHYLPTERINE

Base Information

• Chemical Name: 6-METHYLPTERINE
• CAS No.: 708-75-8
• Molecular Formula: C7H7N5O
• Molecular Weight: 177.165
• Hs Code.: 2933990090
• Mol file: 708-75-8.mol

Synonyms:4(1H)-Pteridinone,2-amino-6-methyl- (8CI,9CI);2-Amino-4-hydroxy-6-methylpteridine;6-Methylpterin;

Chemical Property of 6-METHYLPTERINE

Chemical Property:

• Vapor Pressure: 1.15E-07mmHg at 25°C
• Melting Point: >300 °C
• Refractive Index: 1.842
• Boiling Point: 432 °C at 760 mmHg
• PKA: pKa 2.5(H2O,t undefined,I=0.1) (Uncertain)
• Flash Point: 215.1 °C
• PSA: 97.55000
• Density: 1.76 g/cm³
• LogP: 0.18490
• Storage Temp.: 2-8°C
• Solubility.: Aqueous Acid (Slightly, Heated, Sonicated), Aqueous Base (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

6-Methylpterin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 6-Methylpterin is a derivative of Folic Acid (F680300) which is a precursor of coenzymes involved in metabolism of various nucleotides and nucleic acids.

Technology Process of 6-METHYLPTERINE

There total 23 articles about 6-METHYLPTERINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,5,6-triamino-4-hydroxypyrimidine (1004-75-7) + 2-oxopropanal (78-98-8) → 2-amino-6-methylpteridin-4(1H)-one (708-75-8)

Guidance literature:

2,5,6-triamino-4-hydroxypyrimidine; With sodium sulfite; In water;

2-oxopropanal; With sodium hydrogensulfite; In water; at 5 - 20 ℃;

Reference yield: 80.0%

propylene glycol (57-55-6,63625-56-9) + 2,5,6-triaminopyrimidin-4(3H)-one sulfate → 2-amino-6-methylpteridin-4(1H)-one (708-75-8)

Guidance literature:

With sodium hydrogensulfite; sodium sulfite; In water; at 0 - 20 ℃; for 13h;

Reference yield: 75.0%

2,4,5-triamino-6-hydroxypyrimidine sulfate (35011-47-3) + 2-oxopropanal (78-98-8) → 2-amino-6-methylpteridin-4(1H)-one (708-75-8)

Guidance literature:

With sodium metabisulfite; sodium sulfite; In water; at 0 - 25 ℃; for 16.5h;

DOI:10.1021/jm501945w

upstream raw materials:

methanol

2,5,6-triamino-3,4-dihydro-4-pyrimidinone

1,1-Dichloroacetone

2,4-diamino-6-methylpteridine

Downstream raw materials:

3-Amino-6-methyl-pyrazin-2-carbonsaeure

7-methylpterin

6-Methyl-7,8-dihydropterin

6-methyl-5,6,7,8-tetrahydrobopterin

Refernces

• 1、 Viscontini et al.. "-". . p. 811,813,815,816,817. Retrieved 1971.
• 2、 Quici, Silvio,Casoni, Alessandro,Foschi, Francesca,Armelao, Lidia,Bottaro, Gregorio,Seraglia, Roberta,Bolzati, Cristina,Salvarese, Nicola,Carpanese, Debora,Rosato, Antonio. "Folic acid-conjugated europium complexes as luminescent probes for selective targeting of cancer cells". supporting information. p. 2003 - 2014. Retrieved 2015/04/27.
• 3、 Dantola, M. Laura,Vignoni, Mariana,Capparelli, Alberto L.,Lorente, Carolina,Thomas, Andres H.. "Stability of 7,8-dihydropterins in air-equilibrated aqueous solutions". body text. p. 411 - 425. Retrieved 2009/02/07.