Ethanone, 2-aMino-1-(3-pyridinyl)-

Base Information

• Chemical Name: Ethanone, 2-aMino-1-(3-pyridinyl)-
• CAS No.: 51941-15-2
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.15122
• Mol file: 51941-15-2.mol

Synonyms:Ethanone, 2-aMino-1-(3-pyridinyl)-;2-Amino-1-pyridin-3-yl-ethanone

Chemical Property of Ethanone, 2-aMino-1-(3-pyridinyl)-

Chemical Property:

• PSA: 55.98000
• LogP: 0.92330
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-1-pyridin-3-yl-ethanone 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 2-aMino-1-(3-pyridinyl)-

There total 3 articles about Ethanone, 2-aMino-1-(3-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-pyridin-3-yl-ethanone oxime O-tosylate (74209-51-1) → 3-(α-aminoacetyl)pyridine (51941-15-2)

Guidance literature:

With potassium ethoxide; In ethanol; at 0 - 20 ℃; for 9h;

DOI:10.1080/10286020.2018.1462341

Reference yield:

methyl-3-pyridylketone (350-03-8) → 3-(α-aminoacetyl)pyridine (51941-15-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / methanol / 5 h / Reflux

2: pyridine / 16 h / 0 - 20 °C

3: potassium ethoxide / ethanol / 9 h / 0 - 20 °C

With pyridine; hydroxylamine hydrochloride; potassium ethoxide; In methanol; ethanol;

DOI:10.1080/10286020.2018.1462341

Reference yield:

1-(pyridin-3-yl)ethan-1-one oxime (5973-83-1) → 3-(α-aminoacetyl)pyridine (51941-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / 0 - 20 °C

2: potassium ethoxide / ethanol / 9 h / 0 - 20 °C

With pyridine; potassium ethoxide; In ethanol;

DOI:10.1080/10286020.2018.1462341

upstream raw materials:

methyl-3-pyridylketone

1-(pyridin-3-yl)ethan-1-one oxime

1-pyridin-3-yl-ethanone oxime O-tosylate

Downstream raw materials:

4-Pyridin-3-yl-1H-imidazole-2-thiol

3-(1H-imidazol-4-yl)pyridine

4-(3-pyridyl)-1H-imidazol-1-butanamide phthalimide

(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoic acid [(S)-1-(3-aminomethyl-benzylcarbamoyl)-3-methyl-butyl]-amide

Refernces