2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

Base Information

Chemical Name:2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene
CAS No.:238098-83-4
Molecular Formula:C₃₆H₅₄O₈Si
Molecular Weight:642.905
Hs Code.:

Synonyms:2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

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Chemical Property of 2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

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Technology Process of 2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

There total 8 articles about 2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 237736-52-6
4-(1-ethoxyethyloxy)-3-methoxyphenylacetylene

: 237736-53-7
(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

: 238098-83-4
2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 20 ℃; for 22.5h;
DOI:10.3987/com-99-s63

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 238098-83-4
2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / PPTS / tetrahydrofuran / 30 h / 20 °C

2: 76 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

3: 60 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; hexane; toluene; 1: Etherification / 2: homologation / 3: Sonogashira cross coupling;
DOI:10.3987/com-99-s63

Reference yield:

: 35615-21-5
3-methoxy-4-(ethoxyethylidene-oxy)-benzaldehyde

: 238098-83-4
2-tert-butyldimethylsiloxy-3-(1-ethoxyethoxy)-5-(E)-[3-(1-ethoxyethoxy)-1-propenyl]phenylethynyl 4-(1-ethoxyethoxy)-3-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C / Heating; 3 h

2: 60 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 22.5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; toluene; 1: homologation / 2: Sonogashira cross coupling;
DOI:10.3987/com-99-s63