6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

Base Information

Chemical Name:6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid
CAS No.:1449305-70-7
Molecular Formula:C₂₇H₂₉N₃O₅
Molecular Weight:475.544
Hs Code.:

Synonyms:6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

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Chemical Property of 6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

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Technology Process of 6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

There total 5 articles about 6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 30964-00-2
hept-6-ynoic acid

: 1449305-69-4
t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-70-7
6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 55 ℃; for 30h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-70-7
6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 30 h / 55 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium hydride; triethylamine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1449305-67-2
benzyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-70-7
6-(3-(tert-butoxycarbonylamino)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diaze-pin-7-yl)hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 30 h / 55 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; triethylamine; In tetrahydrofuran; acetic acid;
DOI:10.1016/j.ejmech.2013.05.017