7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

Base Information

Chemical Name:7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid
CAS No.:261763-67-1
Molecular Formula:C₂₉H₃₁ClN₂O₅
Molecular Weight:523.029
Hs Code.:

7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[<i>e</i>]indol-3-yl)-7-oxo-heptanoic acid

Synonyms:7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

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Chemical Property of 7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

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Technology Process of 7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

There total 5 articles about 7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-16-0
heptanedioic acid

: N-(5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl)-acetamide; hydrochloride

: 261763-67-1
7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 12h;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 286374-31-0
7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

: 261763-67-1
7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

2: 4N HCl / dioxane / 5 h / 0 - 23 °C

3: 0.1447 g / Et₃N; EDCI / dimethylformamide / 12 h / 23 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Acetylation / 2: Hydrolysis / 3: Acylation;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

: 261763-67-1
7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / n-Bu₃SnH; AIBN / benzene / 4 h / Heating

2: 96 percent / TBAF / tetrahydrofuran / 1 h / 23 °C

3: 92 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

4: 4N HCl / dioxane / 5 h / 0 - 23 °C

5: 0.1447 g / Et₃N; EDCI / dimethylformamide / 12 h / 23 °C

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; benzene; 1: Cyclization / 2: Substitution / 3: Acetylation / 4: Hydrolysis / 5: Acylation;
DOI:10.1016/S0968-0896(00)00088-2