5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole
CAS No.:1567335-29-8
Molecular Formula:C₂₅H₂₉ClN₂O₂
Molecular Weight:424.97
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

Suppliers and Price of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

There total 12 articles about 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1567335-34-5
trifluoromethanesulfonic acid 2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-2H-pyrazol-3-yl ester

: 1679-18-1
4-Chlorophenylboronic acid

: 1567335-29-8
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 80 ℃; for 6h;

Reference yield:

: 1567335-20-9
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl)-1H-pyrazole

: 1567335-29-8
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 1551.49 Torr;
DOI:10.1016/j.bmcl.2018.10.007

Reference yield:

: 1197-66-6
2,2,6,6-tetramethyltetrahydropyran-4-one

: 1567335-29-8
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / tert-butyl alcohol; 1,2-dimethoxyethane / 0 - 35 °C / Reflux

2: thionyl chloride / dichloromethane / 8 h / 20 °C

3: magnesium bromide diethyl etherate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: ethanol / 4 h / 80 °C

5: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 6 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; magnesium bromide diethyl etherate; potassium tert-butylate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene; tert-butyl alcohol;