4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one

Base Information

• Chemical Name: 4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
• CAS No.: 498568-17-5
• Molecular Formula: C₂₃H₂₀BrN₃O₃
• Molecular Weight: 466.334

Synonyms:4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one

Chemical Property of 4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one

Chemical Property:

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Technology Process of 4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one

There total 2 articles about 4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.5%

3-(1H-imidazol-1-yl)propan-1-amine (5036-48-6) + 2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester (41167-58-2) + 4-bromo-benzaldehyde (1122-91-4) → 4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one (498568-17-5)

Guidance literature:

3-(1H-imidazol-1-yl)propan-1-amine; 4-bromo-benzaldehyde; In 1,4-dioxane; at 30 ℃; for 0.5h;

methyl ester of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

acetophenone (98-86-2) → 4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one (498568-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 3 h / Reflux

2.1: 1,4-dioxane / 0.25 h / 20 °C

2.2: 12 h / 20 °C

In 1,4-dioxane; methanol;

DOI:10.1021/jm300969t

Reference yield: 80.6%

4-benzoyl-5-(4-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one (498568-17-5) → 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (1051871-37-4)

Guidance literature:

With hydrazine hydrate; acetic acid; at 0 ℃; for 6.25h; Reflux;

DOI:10.1021/jm401800k

upstream raw materials:

3-(1H-imidazol-1-yl)propan-1-amine

2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester

4-bromo-benzaldehyde

acetophenone

Downstream raw materials:

C₂₉H₃₀BrN₃O₃

C₃₀H₂₆BrN₃O₃

4-benzoyl-5-(4-bromophenyl)-1-[3-(1H-imidazol-1-yl)propyl]-3-(2-methoxyethoxy)-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₆BrN₃O₃

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