METHYL (2Z)-2-HYDROXY-4-OXO-4-PHENYLBUT-2-ENOATE

Base Information

• Chemical Name: METHYL (2Z)-2-HYDROXY-4-OXO-4-PHENYLBUT-2-ENOATE
• CAS No.: 41167-58-2
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Hs Code.: 2918990090
• Mol file: 41167-58-2.mol

Synonyms:methyl ester of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid;2-BUTENOIC ACID,2-HYDROXY-4-OXO-4-PHENYL-,METHYL;2-HYDROXY-4-OXO-4-PHENYL-BUT-2-ENOIC ACID METHYL ESTER;methyl benzoylpyruvate;benzoylpyruvic ester;

Chemical Property of METHYL (2Z)-2-HYDROXY-4-OXO-4-PHENYLBUT-2-ENOATE

Chemical Property:

• Melting Point: 56-57 °C
• Boiling Point: 336.1±42.0 °C(Predicted)
• PKA: 8.07±0.50(Predicted)
• PSA: 63.60000
• Density: 1.250±0.06 g/cm3(Predicted)
• LogP: 1.48420

Purity/Quality:

99.3% ^*data from raw suppliers

methyl(2Z)-2-hydroxy-4-oxo-4-phenylbut-2-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL (2Z)-2-HYDROXY-4-OXO-4-PHENYLBUT-2-ENOATE

There total 5 articles about METHYL (2Z)-2-HYDROXY-4-OXO-4-PHENYLBUT-2-ENOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

acetophenone (98-86-2) + oxalic acid diethyl ester (95-92-1) → 2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester (41167-58-2)

Guidance literature:

With methanol; sodium methylate; at 70 ℃;

Reference yield: 72.8%

methanol (67-56-1) + sodium methylate (124-41-4) + acetophenone (98-86-2) + oxalic acid diethyl ester (95-92-1) → 2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester (41167-58-2)

Guidance literature:

at 70 ℃;

Reference yield: 65.0%

Dimethyl oxalate (553-90-2) + acetophenone (98-86-2) → 2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester (41167-58-2)

Guidance literature:

Dimethyl oxalate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

acetophenone; In tetrahydrofuran; at 0 - 70 ℃; for 2h; Inert atmosphere;

DOI:10.1002/adsc.202100664

upstream raw materials:

Dimethyl oxalate

acetophenone

sodium methylate

oxalic acid diethyl ester

Downstream raw materials:

methyl 4-oxo-4-phenyl-2-(phenylamino)but-2-enoate

methyl 5-benzoyl-2-oxo-6-phenyl-1,2,3,6-tetrahydropyrimidine-4-carboxylate

C₂₀H₁₈N₂O₆

C₂₁H₂₀N₂O₆