1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Base Information

Chemical Name:1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl
CAS No.:532987-01-2
Molecular Formula:C₃₅H₄₈N₂O₂Si
Molecular Weight:556.864
Hs Code.:

Synonyms:1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Suppliers and Price of 1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

There total 9 articles about 1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130697-96-0
methyl amino(3-hydroxyphenyl)acetate

: 532987-01-2
1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / NaHCO₃ / tetrahydrofuran / 0.5 h / 0 °C

2: K₂CO₃ / acetone / 8 h / Heating

3: 79 percent / LiBH₄ / tetrahydrofuran / 18 h / 0 - 20 °C

4: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

5: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

6: 100 percent / pyridine / 1 h / 0 °C

7: 6.10 g / Cs₂CO₃; Pd(OAc)2; (+/-)-BINAP / toluene / 20 h / 80 °C

With 1H-imidazole; palladium diacetate; lithium borohydride; hydrogen; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 532987-01-2
1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

2: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

3: 100 percent / pyridine / 1 h / 0 °C

4: 6.10 g / Cs₂CO₃; Pd(OAc)2; (+/-)-BINAP / toluene / 20 h / 80 °C

With 1H-imidazole; palladium diacetate; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In pyridine; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

: 111-64-8
n-octanoic acid chloride

: 532987-01-2
1-(tert-butyldimethylsilyloxy)-2-{3-[(diphenylmethylene)amino]phenyl}-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / NaHCO₃ / tetrahydrofuran / 0.5 h / 0 °C

2: K₂CO₃ / acetone / 8 h / Heating

3: 79 percent / LiBH₄ / tetrahydrofuran / 18 h / 0 - 20 °C

4: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

5: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

6: 100 percent / pyridine / 1 h / 0 °C

7: 6.10 g / Cs₂CO₃; Pd(OAc)2; (+/-)-BINAP / toluene / 20 h / 80 °C

With 1H-imidazole; palladium diacetate; lithium borohydride; hydrogen; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0968-0896(02)00381-4