(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

Base Information

Chemical Name:(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate
CAS No.:1204973-72-7
Molecular Formula:C₂₃H₂₆N₆O₃
Molecular Weight:434.498
Hs Code.:

Synonyms:(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

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Chemical Property of (R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

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Technology Process of (R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

There total 4 articles about (R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1204978-36-8
(R)-4-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester

: 108-95-2,27073-41-2
phenol

: 1204973-72-7
(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

Guidance literature:: With potassium phosphate; palladium diacetate; tert-butyl XPhos; In toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 1204973-72-7
(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; potassium carbonate; triethylamine; tert-butyl XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300217

Reference yield:

: 34584-69-5
3,6-dichloro-4,5-dimethylpyridazine

: 1204973-72-7
(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; potassium carbonate; triethylamine; tert-butyl XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300217