2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

Base Information

Chemical Name:2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol
CAS No.:1204973-73-8
Molecular Formula:C₂₄H₃₀N₆O₂
Molecular Weight:434.541
Hs Code.:

Synonyms:2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

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Chemical Property of 2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

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Technology Process of 2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

There total 5 articles about 2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1204973-72-7
(R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate

: 75-16-1
methylmagnesium bromide

: 1204973-73-8
2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

Guidance literature:: (R)-methyl 5-(4-(4,5-dimethyl-6-phenoxypyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazine-2-carboxylate; methylmagnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 1204973-73-8
2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

4: tetrahydrofuran / 3.5 h / -78 - 0 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; potassium carbonate; triethylamine; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300217

Reference yield:

: 34584-69-5
3,6-dichloro-4,5-dimethylpyridazine

: 1204973-73-8
2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2: triethylamine / 1,4-dioxane / 24 h / 80 °C

3: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

4: tetrahydrofuran / 3.5 h / -78 - 0 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; potassium carbonate; triethylamine; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300217