2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

Base Information

Chemical Name:2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine
CAS No.:99484-33-0
Molecular Formula:C₂₀H₂₀Cl₃NO₃
Molecular Weight:428.743
Hs Code.:

Synonyms:2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

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Chemical Property of 2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

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Technology Process of 2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

There total 7 articles about 2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 96842-82-9
2-(3-phenyl-3-dihydrobenzofuranyl)-N,N-dimethylaminoethanamine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 99484-33-0
2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

Guidance literature:: With potassium carbonate; In dichloromethane; at 20 ℃;
DOI:10.1002/jps.2600740112

Reference yield:

: 68240-60-8
α-(2-methoxyphenyl)benzyl chloride

: 99484-33-0
2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 35 percent / acetonitrile / 5 h / Heating

2: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -30 deg C up to 0 deg C, 2.) reflux, 1.5 h

3: 75 percent / 48percent HBr / 40 h / Heating

4: 28 g / lithium tetrahydridoaluminate / diethyl ether / 2 h / 20 °C

5: 14 g / Et₃N / CH₂Cl₂ / 3 h / 5 °C

6: 66 percent / potassium carbonate (anhyd.) / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; potassium carbonate; triethylamine; diisopropylamine; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1002/jps.2600740112

Reference yield:

: 51355-29-4
α-(2-methoxyphenyl)benzeneacetonitrile

: 99484-33-0
2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -30 deg C up to 0 deg C, 2.) reflux, 1.5 h

2: 75 percent / 48percent HBr / 40 h / Heating

3: 28 g / lithium tetrahydridoaluminate / diethyl ether / 2 h / 20 °C

4: 14 g / Et₃N / CH₂Cl₂ / 3 h / 5 °C

5: 66 percent / potassium carbonate (anhyd.) / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; potassium carbonate; triethylamine; diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1002/jps.2600740112