phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

Base Information

Chemical Name:phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate
CAS No.:1254347-08-4
Molecular Formula:C₂₀H₂₁BrO₆
Molecular Weight:437.287
Hs Code.:

Synonyms:phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

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Chemical Property of phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

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Technology Process of phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

There total 10 articles about phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1254347-07-3
phenyl 4-bromo-6-hydroxy-3-methoxy-2-methylbenzoate

: 1254347-08-4
phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

: 877149-05-8
4-bromo-2-methoxy-6-methyl-benzonitrile

: 1254347-08-4
phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C

1.2: 0 - 20 °C

2.1: 2-methyl-but-2-ene; water; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.5 h / 20 °C

2.2: pH 1

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

5.1: boron tribromide / dichloromethane / 0.58 h / -78 - 0 °C

5.2: 0.33 h / 20 °C

6.1: [bis(acetoxy)iodo]benzene / 1,4-dioxane / 0 - 20 °C

6.2: 0.33 h / 20 °C

7.1: dmap / dichloromethane / 0.33 h / 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; [bis(acetoxy)iodo]benzene; water; boron tribromide; diisobutylaluminium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 877149-08-1
4-bromo-2-methoxy-6-methyl-benzoic acid

: 1254347-08-4
phenyl 4-bromo-6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

3.1: boron tribromide / dichloromethane / 0.58 h / -78 - 0 °C

3.2: 0.33 h / 20 °C

4.1: [bis(acetoxy)iodo]benzene / 1,4-dioxane / 0 - 20 °C

4.2: 0.33 h / 20 °C

5.1: dmap / dichloromethane / 0.33 h / 20 °C

With dmap; oxalyl dichloride; [bis(acetoxy)iodo]benzene; boron tribromide; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;