(2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

Base Information

Chemical Name:(2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate
CAS No.:1581734-68-0
Molecular Formula:C₂₁H₂₇F₃O₄
Molecular Weight:400.438
Hs Code.:

Synonyms:(2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

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Chemical Property of (2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

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Technology Process of (2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

There total 3 articles about (2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 100-39-0
benzyl bromide

: 1581734-68-0
(2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

Guidance literature:: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid; benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With triethylamine; In N,N-dimethyl-formamide; for 1h;

Reference yield: 67.0%

: 1581735-07-0
(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 100-39-0
benzyl bromide

: 1581734-68-0
(2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

Guidance literature:: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid; benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With triethylamine; for 1h;

Reference yield:

: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1581734-68-0
(2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene; n-heptane / 0.75 h / -78 - 20 °C

1.2: 0.67 h / -78 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 1 h

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; N,N-dimethyl-formamide;