methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate

Base Information

• Chemical Name: methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate
• CAS No.: 1126318-85-1
• Molecular Formula: C₁₄H₁₃ClFN₃O₄
• Molecular Weight: 341.726
• Mol file: 1126318-85-1.mol

Synonyms:methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate

Chemical Property of methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate

There total 2 articles about methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.6%

(4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid (944129-07-1) + methyl 6-amino-2-chloro-5-methoxy-pyrimidine-4-carboxylate (1126320-49-7) → methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate (1126318-85-1)

Guidance literature:

With palladium diacetate; potassium hydrogencarbonate; triphenylphosphine; In methanol; water; acetonitrile; at 50 ℃; for 22h; Inert atmosphere;

Reference yield: 47.0%

methanol (67-56-1) + 6-Chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidin-4-ylamine (1126320-83-9) + carbon monoxide (201230-82-2) → methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate (1126318-85-1)

Guidance literature:

With triethylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate; at 125 ℃; for 18h; under 15514.9 Torr;

Reference yield: 75.0%

methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate (1126318-85-1) → 6-hydroxy-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid methyl ester (1190410-23-1)

Guidance literature:

methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate; With sulfuric acid; water; sodium nitrite; In acetonitrile;

With sodium hydroxide; In acetonitrile; pH=~ 0.8; Cooling with ice-salt;

upstream raw materials:

(4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid

methyl 6-amino-2-chloro-5-methoxy-pyrimidine-4-carboxylate

methanol

6-Chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidin-4-ylamine

Downstream raw materials:

6-hydroxy-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylic acid methyl ester