(R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate

Base Information

• Chemical Name: (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate
• CAS No.: 369611-56-3
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.282
• Mol file: 369611-56-3.mol

Synonyms:(R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate

Chemical Property of (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate

There total 8 articles about (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid → (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate (369611-56-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; for 5h;

Reference yield: 76.0%

D-2-<(benzyloxycarbonyl)amino>-4-butyrolactone (41088-89-5) + methyl iodide (74-88-4) → (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate (369611-56-3)

Guidance literature:

D-2-<(benzyloxycarbonyl)amino>-4-butyrolactone; With potassium hydroxide; In methanol; at 20 ℃; for 18h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 66h;

DOI:10.1139/v03-122

Reference yield:

(R)-2-benzyloxycarbonylamino-4-hydroxybutyric acid, dicyclohexylamine salt (1159502-39-2) + methyl iodide (74-88-4) → (R)-methyl 2-(((benzyloxy)carbonyl)amino)-4-hydroxybutanoate (369611-56-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

D-2-<(benzyloxycarbonyl)amino>-4-butyrolactone

methyl iodide

(2R)-2-[[(benzyloxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid

benzyl chloroformate

Downstream raw materials:

(R)-2-benzyloxycarbonylamino-4-bromo-butyric acid methyl ester

4-[(R)-2-benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyryl]-piperazine-1-carboxylic acid ethyl ester

(R)-2-benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid methyl ester

(R)-2-benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid