N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide

Base Information

• Chemical Name: N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide
• CAS No.: 1403961-73-8
• Molecular Formula: C₁₉H₂₁NO₂S₂
• Molecular Weight: 359.513
• Mol file: 1403961-73-8.mol

Synonyms:N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide

Chemical Property of N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide

There total 3 articles about N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cyclohex-2-enyl phenyl sulfide (134427-69-3,3467-73-0) + chloroamine-T (127-65-1) → N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide (1403961-73-8)

Guidance literature:

In ethanol; at 20 ℃; Green chemistry;

DOI:10.1002/cjoc.201200604

Reference yield: 53.0%

[N-(p-tolylsulfonyl)imino]phenyliodinane (55962-05-5) + cyclohex-2-enyl phenyl sulfide (134427-69-3,3467-73-0) → N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide (1403961-73-8)

Guidance literature:

With iodine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.202000961

Reference yield:

thiophenol (108-98-5) + rac-3-bromocyclohexene (1521-51-3,113667-32-6) → N-(cyclohex-2-en-1-yl)-4-methyl-N-(phenylthio)benzenesulfonamide (1403961-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 20 °C

2.1: ethanol / 20 °C / Green chemistry

With sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1002/cjoc.201200604

upstream raw materials:

cyclohex-2-enyl phenyl sulfide

chloroamine-T

thiophenol

rac-3-bromocyclohexene

Downstream raw materials:

N-cyclohex-2-enyl-4-methyl-benzenesulfonamide