(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Base Information

Chemical Name:(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol
CAS No.:1352571-42-6
Molecular Formula:C₂₈H₂₈N₂O₇S
Molecular Weight:536.606
Hs Code.:

Synonyms:(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

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Chemical Property of (2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

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Technology Process of (2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

There total 10 articles about (2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 455-15-2
1-(methylsufonyl)-4-fluorobenzene

: 1352571-00-6
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((S)-1-(tert-butyldimethylsilyloxy)propan-2-yloxy)phenol

: 1352571-42-6
(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; Sealed tube;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-42-6
(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / -70 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; triphenylphosphine; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling / 4.1: Mitsunobu reaction;

Reference yield:

: 480998-38-7
2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine

: 1352571-42-6
(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 3: Mitsunobu reaction;