1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

Base Information

Chemical Name:1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate
CAS No.:373633-79-5
Molecular Formula:CH₄O₃S*C₃₀H₄₃N₃O₄
Molecular Weight:605.796
Hs Code.:

1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

Synonyms:1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

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Chemical Property of 1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

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Technology Process of 1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

There total 7 articles about 1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 373633-77-3
1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

: 373633-79-5
1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

Guidance literature:: In dichloromethane;

Reference yield:

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 373633-79-5
1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; hydrogen bromide / 72 h / Heating / reflux

2.1: hydrogenchloride / water / 8 h / 80 °C

2.2: 12 h / 49 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

4.1: potassium carbonate / DMF (N,N-dimethyl-formamide)

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2.67 h / 23 - 40 °C

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 20 °C

7.1: dichloromethane

With hydrogenchloride; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; hydrogen bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane; water;

Reference yield:

: 588-05-6
m-tyramine

: 373633-79-5
1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 2 h / 4 - 20 °C

2: hydrogenchloride / 48 h / Heating / reflux

3: triethylamine / tetrahydrofuran / 2 h / 20 °C

4: potassium carbonate / DMF (N,N-dimethyl-formamide)

5: sodium hydroxide; water / tetrahydrofuran; methanol / 2.67 h / 23 - 40 °C

6: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 20 °C

7: dichloromethane

With hydrogenchloride; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;