1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1374006-83-3
Molecular Formula:C₂₂H₂₈F₃N₅O₄S
Molecular Weight:515.557
Hs Code.:

Synonyms:1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of 1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 7 articles about 1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129768-24-7
1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

: 110-91-8,99108-56-2
morpholine

: 1374007-00-7
C₁₂H₁₄N₂O₅S

: 1374006-83-3
1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: morpholine; C₁₂H₁₄N₂O₅S; With sodium tris(acetoxy)borohydride; In dichloromethane;

With palladium on activated charcoal; hydrogen; In methanol;

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)aniline

: 128694-63-3
1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid

: 1374006-83-3
1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h;

4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;
DOI:10.1021/jm201699w

Reference yield:

: 349098-93-7
C₁₂H₁₆N₂O₅S

: 1374006-83-3
1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C

3.1: tin(II) chloride dihdyrate / methanol; dichloromethane

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

4.2: 2 h

With oxalyl dichloride; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; N,N-dimethyl-formamide; pyridinium chlorochromate; In methanol; dichloromethane;
DOI:10.1021/jm201699w