Technology Process of 4-bromo-2-cyclopropoxy-1-difluoromethoxybenzene
There total 5 articles about 4-bromo-2-cyclopropoxy-1-difluoromethoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
tetrabutylammomium bromide;
In
water; toluene;
at 80 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C
2: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 3 h / 20 °C
3: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C
4: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C
5: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C
With
sodium hydroxide; dimethyl zinc(II); boron tribromide; potassium carbonate;
tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate;
In
dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C
2: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C
3: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C
With
sodium hydroxide; dimethyl zinc(II); boron tribromide;
tetrabutylammomium bromide;
In
dichloromethane; water; toluene;
