5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one

Base Information

• Chemical Name: 5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one
• CAS No.: 1312704-81-6
• Molecular Formula: C₂₀H₁₁F₆N₃OS₂
• Molecular Weight: 487.449

Synonyms:5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one

Chemical Property of 5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one

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Technology Process of 5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one

There total 1 articles about 5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thioxo-4-thiazolidinone (141-84-4) + 1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazole-5-carbaldehyde (1312704-79-2) → 5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one (1312704-81-6)

Guidance literature:

With ammonium acetate; acetic acid; at 95 ℃; for 2h;

Reference yield:

5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one (1312704-81-6) + ethyl iodide (75-03-6) → 5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-ethylsulfanylthiazol-4-one (1312704-82-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-thioxothiazolidin-4-one (1312704-81-6) + methyl iodide (74-88-4) → C21H13F6N3OS2 (1312705-81-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

2-thioxo-4-thiazolidinone

1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazole-5-carbaldehyde

Downstream raw materials:

1-{5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-4-oxo-4,5-dihydrothiazol-2-yl}piperidine-4-carboxylic acid

C₂₁H₁₃F₆N₃OS₂

5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-2-ethylsulfanylthiazol-4-one

1-{5-[(1-(2,4-bis-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene]-4-oxo-4,5-dihydrothiazol-2-yl}piperidine-4-carboxylic acid amide

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