(2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran

Base Information

Chemical Name:(2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran
CAS No.:1304073-48-0
Molecular Formula:C₃₆H₃₇N₃O₆
Molecular Weight:607.706
Hs Code.:

Synonyms:(2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran

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Technology Process of (2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran

There total 2 articles about (2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 960071-95-8
(2R,3S,5R)-2-(4,4′-dimethoxytrityloxymethyl)-5-ethynyl-3-hydroxytetrahydrofuran

: 511541-62-1
6-amino-5-bromo-2(1H)-pyridone

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1304073-48-0
(2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran

Guidance literature:: (2R,3S,5R)-2-(4,4′-dimethoxytrityloxymethyl)-5-ethynyl-3-hydroxytetrahydrofuran; 6-amino-5-bromo-2(1H)-pyridone; N,N-dimethyl-formamide; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenylphosphine; at 120 ℃; for 1h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.3987/COM-10-S(E)89

Reference yield: 11.0%

: 960071-95-8
(2R,3S,5R)-2-(4,4′-dimethoxytrityloxymethyl)-5-ethynyl-3-hydroxytetrahydrofuran

: 511541-62-1
6-amino-5-bromo-2(1H)-pyridone

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 1304073-48-0
(2R,3S,5R)-5-(6-(dimethylaminomethyleneamino)-2(1H)-pyridinon-5-ylethynyl)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxytetrahydrofuran

: 1304073-50-4
C₃₉H₄₅N₃O₆Si

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 90 ℃; for 3.5h; Inert atmosphere;
DOI:10.3987/COM-10-S(E)89