benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

Base Information

Chemical Name:benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate
CAS No.:1352835-79-0
Molecular Formula:C₂₇H₂₈FN₃O₄
Molecular Weight:477.535
Hs Code.:

Synonyms:benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

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Chemical Property of benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

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Technology Process of benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

There total 8 articles about benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1352835-78-9
benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate

: 1352835-79-0
benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

Guidance literature:: benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate; With ammonium chloride; zinc; In tetrahydrofuran; methanol; for 3h; Inert atmosphere;

With sodium hydrogencarbonate; In water; pH=~ 11;

Reference yield:

: 2380-86-1
6-hydroxy-1H-indole

: 1352835-79-0
benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

2.1: 125 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere

3.2: pH ~ 11

With ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1352835-79-0
benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C / Inert atmosphere

2.2: 1.33 h / Cooling with ice

3.1: acetic acid / 2 h / 90 °C / Inert atmosphere

4.1: 125 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere

5.2: pH ~ 11

With diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane;