Technology Process of benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate
There total 8 articles about benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate;
With
ammonium chloride; zinc;
In
tetrahydrofuran; methanol;
for 3h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
water;
pH=~ 11;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C
2.1: 125 °C
3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere
3.2: pH ~ 11
With
ammonium chloride; caesium carbonate; zinc;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / tetrahydrofuran / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C / Inert atmosphere
2.2: 1.33 h / Cooling with ice
3.1: acetic acid / 2 h / 90 °C / Inert atmosphere
4.1: 125 °C
5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere
5.2: pH ~ 11
With
diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane;
