benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate

Base Information

• Chemical Name: benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate
• CAS No.: 1352835-78-9
• Molecular Formula: C₂₇H₂₆FN₃O₆
• Molecular Weight: 507.518
• Mol file: 1352835-78-9.mol

Synonyms:benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate

Chemical Property of benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate

There total 6 articles about benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.2%

(E)-benzyl 2-fluoro-3-(2-nitrovinyl)phenylcarbamate (1352835-77-8) + 6-(2-methoxyethoxy)-1H-indole (158865-46-4) → benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate (1352835-78-9)

Guidance literature:

at 125 ℃;

Reference yield:

6-hydroxy-1H-indole (2380-86-1) → benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate (1352835-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

2: 125 °C

With caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-fluoro-3-(1-(6-(2-methoxyethoxy)-1H-indol-3-yl)-2-nitroethyl)phenylcarbamate (1352835-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C / Inert atmosphere

2.2: 1.33 h / Cooling with ice

3.1: acetic acid / 2 h / 90 °C / Inert atmosphere

4.1: 125 °C

With diisobutylaluminium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane;

upstream raw materials:

6-hydroxy-1H-indole

benzyl chloroformate

3-amino-2-fluorobenzonitrile

benzyl 3-cyano-2-fluorophenylcarbamate

Downstream raw materials:

benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate

ethyl 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

benzyl 3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-fluorophenylcarbamate