(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

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Chemical Name:(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol
CAS No.:193416-47-6
Molecular Formula:C₄₉H₇₄O₈Si₂
Molecular Weight:847.293
Hs Code.:

(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

Synonyms:(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

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Chemical Property of (2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

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Technology Process of (2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

There total 11 articles about (2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193416-38-5
(2R,6R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-[2-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-4-one

: 193416-47-6
(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / K(s-Bu₃BH) / tetrahydrofuran

2: 93 percent / Et₃N

3: 97 percent / DDQ / CH₂Cl₂

4: 80 percent

5: CrCl₂/NiCl₂ / tetrahydrofuran

6: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

With chromium dichloride; potassium tri-sec-butyl-borohydride; potassium carbonate; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9708755

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 193416-47-6
(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / Et₃N

2: 97 percent / DDQ / CH₂Cl₂

3: 80 percent

4: CrCl₂/NiCl₂ / tetrahydrofuran

5: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

With chromium dichloride; potassium carbonate; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9708755

Reference yield:

: 193416-55-6
(2R,4R,6R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-[2-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-4-ol

: 193416-47-6
(2S,6R)-1-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-yl]-8-(4-methoxy-benzyloxy)-4-methylene-6-triethylsilanyloxy-octan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / Et₃N

2: 97 percent / DDQ / CH₂Cl₂

3: 80 percent

4: CrCl₂/NiCl₂ / tetrahydrofuran

5: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

With chromium dichloride; potassium carbonate; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9708755