(Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

Base Information

Chemical Name:(Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide
CAS No.:1338221-24-1
Molecular Formula:C₃₈H₄₉N₃O₃Si₂
Molecular Weight:651.996
Hs Code.:

Synonyms:(Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

Chemical Property:

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Technology Process of (Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

There total 12 articles about (Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 1338221-21-8
5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(phenylethynyl)pyrazin-2-amine

: 1338221-24-1
(Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

: 1338221-22-9
2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethylsilyloxy)phenyl}-3-(phenylethynyl)pyrazin-2-yl]acetamide

: 1338221-26-3
2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethylsilyloxy)phenyl}-3-phenethylpyrazin-2-yl]acetamide

Guidance literature:: 5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(phenylethynyl)pyrazin-2-amine; With 10 percent palladium on barium sulphate; hydrogen; In ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride; With pyridine; dmap; at 50 ℃; for 20h; Overall yield = 60 mg; Inert atmosphere;

Reference yield:

: 79-37-8
oxalyl dichloride

: 114774-40-2
2-(4-((tert-butyldimethylsilyl)oxy)phenyl)acetic acid

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 1338221-24-1
(Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

Guidance literature:: In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 1338221-24-1
(Z)-2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-{5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-styrylpyrazin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium carbonate / tetrahydrofuran

2: dichloromethane; N,N-dimethyl-formamide

With hydrogenchloride; sodium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;