4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene

Base Information

• Chemical Name: 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene
• CAS No.: 1651213-99-8
• Molecular Formula: C₁₉H₁₈O₃
• Molecular Weight: 294.35
• Mol file: 1651213-99-8.mol

Synonyms:4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene

Chemical Property of 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene

There total 3 articles about 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-2-(2-(4-methoxyphenyl)ethynyl)benzaldehyde (1185881-82-6) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene (1651213-99-8)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

5-methoxy-2-(2-(4-methoxyphenyl)ethynyl)benzaldehyde; In tetrahydrofuran; at -78 - 0 ℃; for 3h;

DOI:10.1039/c8ob02582g

Reference yield:

4-methoxyphenylacetylen (768-60-5) → 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene (1651213-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 50 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 3 h / -78 - 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran;

DOI:10.1039/c8ob02582g

Reference yield:

2-bromo-5-methoxy-benzaldehyde (7507-86-0) → 4-methoxy-1-((4-methoxyphenyl)ethynyl)-2-(2-methoxyvinyl)benzene (1651213-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 50 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 3 h / -78 - 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran;

DOI:10.1039/c8ob02582g

upstream raw materials:

5-methoxy-2-(2-(4-methoxyphenyl)ethynyl)benzaldehyde

(methoxymethyl)triphenylphosphonium chloride

4-methoxyphenylacetylen

2-bromo-5-methoxy-benzaldehyde

Downstream raw materials:

1,6-dimethoxy-2-(4-methoxyphenyl)naphthalene