2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

Base Information

Chemical Name:2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide
CAS No.:908344-58-1
Molecular Formula:C₁₈H₂₃NO₈S
Molecular Weight:413.449
Hs Code.:

Synonyms:2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

Chemical Property:

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Technology Process of 2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

There total 5 articles about 2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1445727-08-1
N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

: 908344-58-1
2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm400575x

Reference yield:

: 1687-53-2
5-amino-2-methoxyphenol

: 908344-58-1
2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water / 3 h / 20 °C / Inert atmosphere

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 4 h / 20 °C / Inert atmosphere

5: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm400575x

Reference yield:

: 1445727-01-4
ethyl 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetate

: 908344-58-1
2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water / 3 h / 20 °C / Inert atmosphere

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: aluminum (III) chloride / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm400575x