(1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

Base Information

Chemical Name:(1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol
CAS No.:915158-83-7
Molecular Formula:C₃₈H₄₄O₈
Molecular Weight:628.763
Hs Code.:

Synonyms:(1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

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Chemical Property of (1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

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Technology Process of (1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

There total 7 articles about (1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 915158-73-5
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-one

: 915158-83-7
(1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

: (1S,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

Guidance literature:: With Amberlite IRA-400-supported borohydride; In methanol; at 20 ℃; for 16h;
DOI:10.1021/ol0621710

Reference yield:

: 915158-67-7
4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenol

: 915158-83-7
(1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / BEMP / CH₂Cl₂ / -45 - 0 °C

2: 95 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

3: 96 percent / tetrahydrofuran / -30 - 0 °C

4: 75 percent / Amberlite IRA-400-supported borohydride / methanol / 16 h / 20 °C

With Amberlite IRA-400-supported borohydride; dimethylaluminum chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol0621710

Reference yield:

: 915158-70-2
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-propionic acid methyl ester

: 915158-83-7
(1R,2R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-(3,4-dimethoxy-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

2: 96 percent / tetrahydrofuran / -30 - 0 °C

3: 75 percent / Amberlite IRA-400-supported borohydride / methanol / 16 h / 20 °C

With Amberlite IRA-400-supported borohydride; dimethylaluminum chloride; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol0621710