(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

Base Information

Chemical Name:(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide
CAS No.:915158-84-8
Molecular Formula:C₃₆H₄₇NO₁₀
Molecular Weight:653.77
Hs Code.:

(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

Synonyms:(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

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Chemical Property of (S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

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Technology Process of (S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

There total 10 articles about (S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 915158-74-6
(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-propionic acid methyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 915158-84-8
(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol0621710

Reference yield:

: 915158-67-7
4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenol

: 915158-84-8
(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / BEMP / CH₂Cl₂ / -45 - 0 °C

2: 95 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

3: 96 percent / tetrahydrofuran / -30 - 0 °C

4: 75 percent / Amberlite IRA-400-supported borohydride / methanol / 16 h / 20 °C

5: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 1 h / 20 °C

6: 83 percent / BEMP / CH₂Cl₂ / 0.67 h / -45 °C

7: 88 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

With Amberlite IRA-400-supported borohydride; hydrogen; dimethylaluminum chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate;
DOI:10.1021/ol0621710

Reference yield:

: 915158-70-2
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-propionic acid methyl ester

: 915158-84-8
(S)-2-[4-((2S,3R,4R,5S)-5-{4-[(1R,2R)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

2: 96 percent / tetrahydrofuran / -30 - 0 °C

3: 75 percent / Amberlite IRA-400-supported borohydride / methanol / 16 h / 20 °C

4: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 1 h / 20 °C

5: 83 percent / BEMP / CH₂Cl₂ / 0.67 h / -45 °C

6: 88 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

With Amberlite IRA-400-supported borohydride; hydrogen; dimethylaluminum chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate;
DOI:10.1021/ol0621710