2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester

Base Information

• Chemical Name: 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester
• CAS No.: 340291-84-1
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.412
• Mol file: 340291-84-1.mol

Synonyms:2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester

Chemical Property of 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester

There total 4 articles about 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

2-(sulfinylamino)benzoyl chloride (64001-48-5) + 2-amino-5-benzyloxybenzoic acid methyl ester (116027-17-9) → 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester (340291-84-1)

Guidance literature:

In toluene; at 20 ℃; for 48h;

DOI:10.1021/jo001696h

Reference yield:

2-amino-5-hydroxybenzoic acid (394-31-0) → 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester (340291-84-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / conc. H₂SO₄ / 48 h / Heating

2: 78 percent / ethanol / 3 h / 40 - 50 °C

3: 95 percent / K₂CO₃ / acetone / 3.5 h / Heating

4: 95 percent / hydrogen chloride / methanol / 8 h / Heating

5: 27 percent / toluene / 48 h / 20 °C

With hydrogenchloride; sulfuric acid; potassium carbonate; In methanol; ethanol; acetone; toluene;

DOI:10.1021/jo001696h

Reference yield:

methyl 2-amino-5-hydroxybenzoate (1882-72-0) → 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester (340291-84-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / ethanol / 3 h / 40 - 50 °C

2: 95 percent / K₂CO₃ / acetone / 3.5 h / Heating

3: 95 percent / hydrogen chloride / methanol / 8 h / Heating

4: 27 percent / toluene / 48 h / 20 °C

With hydrogenchloride; potassium carbonate; In methanol; ethanol; acetone; toluene;

DOI:10.1021/jo001696h

upstream raw materials:

2-(sulfinylamino)benzoyl chloride

2-amino-5-benzyloxybenzoic acid methyl ester

2-amino-5-hydroxybenzoic acid

methyl 2-amino-5-hydroxybenzoate

Downstream raw materials:

2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

Refernces