2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

Base Information

Chemical Name:2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester
CAS No.:340291-85-2
Molecular Formula:C₃₃H₃₁N₃O₇
Molecular Weight:581.625
Hs Code.:

Synonyms:2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

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Chemical Property of 2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

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Technology Process of 2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

There total 6 articles about 2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1142-20-7
N-Cbz-Ala

: 340291-84-1
2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester

: 340291-85-2
2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jo001696h

Reference yield:

: 394-31-0
2-amino-5-hydroxybenzoic acid

: 340291-85-2
2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / conc. H₂SO₄ / 48 h / Heating

2: 78 percent / ethanol / 3 h / 40 - 50 °C

3: 95 percent / K₂CO₃ / acetone / 3.5 h / Heating

4: 95 percent / hydrogen chloride / methanol / 8 h / Heating

5: 27 percent / toluene / 48 h / 20 °C

6: 63 percent / DCC / CH₂Cl₂ / 20 °C

With hydrogenchloride; sulfuric acid; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; acetone; toluene;
DOI:10.1021/jo001696h

Reference yield:

: 1882-72-0
methyl 2-amino-5-hydroxybenzoate

: 340291-85-2
2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]-5-benzyloxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / ethanol / 3 h / 40 - 50 °C

2: 95 percent / K₂CO₃ / acetone / 3.5 h / Heating

3: 95 percent / hydrogen chloride / methanol / 8 h / Heating

4: 27 percent / toluene / 48 h / 20 °C

5: 63 percent / DCC / CH₂Cl₂ / 20 °C

With hydrogenchloride; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; acetone; toluene;
DOI:10.1021/jo001696h