2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

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Chemical Name:2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester
CAS No.:438526-45-5
Molecular Formula:C₂₆H₂₅N₃O₁₀
Molecular Weight:539.499
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

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Chemical Property of 2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

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Technology Process of 2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

There total 6 articles about 2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 438526-44-4
2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-hydroxymethyl-phenyl ester

: 438526-45-5
2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0968-0896(01)00145-6

Reference yield:

: 89-56-5
5-Methylsalicylic acid

: 438526-45-5
2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: N-bromosuccinimide; azobis(isobutyronitrile) / CCl₄ / 1 h / 80 °C / Irradiation

3: silver nitrate / dioxane; H₂O / 16 h / 20 °C

4: 50 percent / triethylamine; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 36.5 h / 0 - 20 °C

5: 88 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; tetrachloromethane; dichloromethane; water;
DOI:10.1016/S0968-0896(01)00145-6

Reference yield:

: 3282-30-2
pivaloyl chloride

: 438526-45-5
2,2-dimethyl-propionic acid 2-[(2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl)carbamoyl]-4-(4-nitro-phenoxycarbonyloxymethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: N-bromosuccinimide; azobis(isobutyronitrile) / CCl₄ / 1 h / 80 °C / Irradiation

3: silver nitrate / dioxane; H₂O / 16 h / 20 °C

4: 50 percent / triethylamine; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 36.5 h / 0 - 20 °C

5: 88 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; tetrachloromethane; dichloromethane; water;
DOI:10.1016/S0968-0896(01)00145-6