(3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 407623-72-7
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Mol file: 407623-72-7.mol

Synonyms:tert-butyl N-[3-(hydroxymethyl)pyridin-4-yl]carbamate

Chemical Property of (3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 1 articles about (3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-amino-3-hydroxymethylpyridine (138116-34-4) → tert-butyl N-[3-(hydroxymethyl)pyridin-4-yl]carbamate (407623-72-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h; Time;

Reference yield:

tert-butyl N-[3-(hydroxymethyl)pyridin-4-yl]carbamate (407623-72-7) → C18H19FN2O3

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: 3-(2,6-diethylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; caesium carbonate / 1,4-dioxane / 36 h / 23 °C / Inert atmosphere; Glovebox

With pyridine; thionyl chloride; 3-(2,6-diethylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; caesium carbonate; In 1,4-dioxane; dichloromethane;

DOI:10.1039/c6cc04735a

Reference yield:

tert-butyl N-[3-(hydroxymethyl)pyridin-4-yl]carbamate (407623-72-7) → 2-phenyl-1H-pyrrolo[3,2-c]pyridine (37388-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: 3-(2,6-diethylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; caesium carbonate / 1,4-dioxane / 36 h / 23 °C / Inert atmosphere; Glovebox

3: methanesulfonic acid / 40 °C / Inert atmosphere

With pyridine; thionyl chloride; methanesulfonic acid; 3-(2,6-diethylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; caesium carbonate; In 1,4-dioxane; dichloromethane;

DOI:10.1039/c6cc04735a

upstream raw materials:

di-tert-butyl dicarbonate

4-amino-3-hydroxymethylpyridine

Downstream raw materials:

2-phenyl-1H-pyrrolo[3,2-c]pyridine

2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Refernces