dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate

Base Information

• Chemical Name: dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate
• CAS No.: 1253976-16-7
• Molecular Formula: C₃₃H₄₆N₂O₅
• Molecular Weight: 550.739
• Mol file: 1253976-16-7.mol

Synonyms:dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate

Chemical Property of dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate

There total 1 articles about dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

methanol (67-56-1) + methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8) + benzylamine (100-46-9) → methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate (1253976-16-7)

Guidance literature:

In dichloromethane; for 48h; regioselective reaction;

DOI:10.1134/S1070428010080051

Reference yield: 78.0%

Glyoxal (131543-46-9,107-22-2) + dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate (1253976-16-7) → dimethyl (1R,4aR,7R,8R)-8-(3-benzyl-2,4-dioxoimidazolidin-1-yl)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate (1253976-28-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 1h; Reflux;

DOI:10.1134/S1070428010080051

Reference yield: 55.0%

dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate (1253976-16-7) → methyl (4aS,7R,10aR,12aR)-2-benzyl-4b,12-(13-isopropyletheno)-7,10a-dimethyl-1,3-dioxooctadecahydronaphtho[1,2-h]quinazoline-7-carboxylate (1253976-31-6)

Guidance literature:

With sodium ethanolate; In ethanol; at 60 ℃;

DOI:10.1134/S1070428010080051

upstream raw materials:

methanol

methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

benzylamine

Downstream raw materials:

methyl (4aS,7R,10aR,12aR)-2-benzyl-4b,12-(13-isopropyletheno)-7,10a-dimethyl-1,3-dioxooctadecahydronaphtho[1,2-h]quinazoline-7-carboxylate

dimethyl (3R,3aR,9R,12aR)-5-benzylamino-2,6-(isopropylidenemethano)-9,12a-dimethyl-1,2,3,3a,6,7,8,8a,9,10,11,12,12a,12b-tetradecahydronaphtho[2,1-d]indole-3,9-dicarboxylate

dimethyl (1R,4aR,7R,8R)-8-(3-benzyl-2,4-dioxoimidazolidin-1-yl)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate