methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

Base Information

• Chemical Name: methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate
• CAS No.: 1160170-64-8
• Molecular Formula: C₃₂H₄₁NO₇S
• Molecular Weight: 583.746
• Mol file: 1160170-64-8.mol

Synonyms:

Chemical Property of methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

There total 1 articles about methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + p-toluenesulfonyl chloride (98-59-9) → methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1134/S0012500808110098

Reference yield: 49.0%

methanol (67-56-1) + methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8) + benzylamine (100-46-9) → methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate (1253976-16-7)

Guidance literature:

In dichloromethane; for 48h; regioselective reaction;

DOI:10.1134/S1070428010080051

Reference yield: 43.0%

methanol (67-56-1) + methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8) + aniline (62-53-3) → methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + dimethyl (1R,4aR,7R,8R,11aR)-1,4a-dimethyl-6,8a-(11-isopropyletheno)-8-(3-phenylureido)tetradecahydrophenanthrene-1,7-dicarboxylate

Guidance literature:

With triethylamine; for 2h; Reflux;

DOI:10.1134/S0012500808110098

upstream raw materials:

methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

p-toluenesulfonyl chloride

Downstream raw materials:

methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

C₃₂H₄₄N₂O₅

dimethyl (1R,4aR,7R,8R)-6,8a-(11-isopropyletheno)-1,4a-dimethyl-8-(3-phenylaminoureido)tetradecahydrophenanthrene-1,7-dicarboxylate

dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate