methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

Base Information

• Chemical Name: methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate
• CAS No.: 1160170-63-7
• Molecular Formula: C₂₅H₃₅NO₅
• Molecular Weight: 429.557
• Mol file: 1160170-63-7.mol

Synonyms:

Chemical Property of methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

There total 4 articles about methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

methanol (67-56-1) + methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8) + benzylamine (100-46-9) → methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + dimethyl (1R,4aR,7R,8R)-8-(3-benzylureido)-6,8a-(11-isopropyletheno)-1,4a-dimethyltetradecahydrophenanthrene-1,7-dicarboxylate (1253976-16-7)

Guidance literature:

In dichloromethane; for 48h; regioselective reaction;

DOI:10.1134/S1070428010080051

Reference yield: 43.0%

methanol (67-56-1) + methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8) + aniline (62-53-3) → methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + dimethyl (1R,4aR,7R,8R,11aR)-1,4a-dimethyl-6,8a-(11-isopropyletheno)-8-(3-phenylureido)tetradecahydrophenanthrene-1,7-dicarboxylate

Guidance literature:

With triethylamine; for 2h; Reflux;

DOI:10.1134/S0012500808110098

Reference yield: 31.0%

methanol (67-56-1) + methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-64-8) + phenylhydrazine (100-63-0) → methyl (3aR,6R,9aR,11aR)-2-hydroxy-3b,11-(12-isopropyletheno)-6,9a-dimethyl-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate (1160170-63-7) + dimethyl (1R,4aR,7R,8R)-6,8a-(11-isopropyletheno)-1,4a-dimethyl-8-(3-phenylaminoureido)tetradecahydrophenanthrene-1,7-dicarboxylate (1253976-20-3)

Guidance literature:

With triethylamine; for 2h; regioselective reaction; Reflux;

DOI:10.1134/S1070428010080051

upstream raw materials:

methanol

methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate

aniline

phenylhydrazine

Downstream raw materials:

methyl (3aR,6R,9aR,11aR)-3b,11-(12-isopropyletheno)-6,9a-dimethyl-2-(4-methylphenylsulfonyloxy)-1,3-dioxohexadecahydro-1H-naphtho[2,1-e]isoindole-6-carboxylate