methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Base Information

Chemical Name:methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate
CAS No.:1389326-75-3
Molecular Formula:C₁₉H₁₈ClFN₂O₂
Molecular Weight:360.816
Hs Code.:

Synonyms:methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

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Chemical Property of methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Chemical Property:

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Technology Process of methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

There total 5 articles about methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389326-74-2
methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

: 1389326-75-3
methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 2h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-75-3
methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

4.2: 4 h / 20 °C

5.1: hydrogenchloride / methanol / 2 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; sodium hydrogencarbonate; 10% Pt/activated carbon; In 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 4769-97-5
4-nitro-1H-indoIe

: 1389326-75-3
methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

4.2: 4 h / 20 °C

5.1: hydrogenchloride / methanol / 2 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; sodium hydrogencarbonate; 10% Pt/activated carbon; In 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;