Technology Process of methyl 2-(4-chlorophenyl)-4-fluoro-2-(4-(methylsulfonamido)-1H-indol-1-yl)butanoate
There total 6 articles about methyl 2-(4-chlorophenyl)-4-fluoro-2-(4-(methylsulfonamido)-1H-indol-1-yl)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
1.2: 3 h / 0 °C
2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere
3.1: sodium hydrogencarbonate / 1,4-dioxane; water
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere
4.2: 4 h / 20 °C
5.1: hydrogenchloride / methanol / 2 h / 20 °C
6.1: 4-methyl-morpholine / dichloromethane / 4 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydride; sodium hydrogencarbonate;
10% Pt/activated carbon;
In
1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
1.2: 3 h / 0 °C
2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere
3.1: sodium hydrogencarbonate / 1,4-dioxane; water
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere
4.2: 4 h / 20 °C
5.1: hydrogenchloride / methanol / 2 h / 20 °C
6.1: 4-methyl-morpholine / dichloromethane / 4 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydride; sodium hydrogencarbonate;
10% Pt/activated carbon;
In
1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;