methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Base Information

• Chemical Name: methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate
• CAS No.: 1389326-74-2
• Molecular Formula: C₂₄H₂₆ClFN₂O₄
• Molecular Weight: 460.933
• Mol file: 1389326-74-2.mol

Synonyms:methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Chemical Property of methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

There total 4 articles about methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-fluoro-2-iodoethane (762-51-6) + methyl {4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}(4-chlorophenyl)acetate (1389326-21-9) → methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate (1389326-74-2)

Guidance literature:

methyl {4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}(4-chlorophenyl)acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

1-fluoro-2-iodoethane; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 4h;

Reference yield:

methyl 2-bromo-2-(4-chlorophenyl)acetate (24091-92-7) → methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate (1389326-74-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

4.2: 4 h / 20 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; 10% Pt/activated carbon; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

4-nitro-1H-indoIe (4769-97-5) → methyl 2-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate (1389326-74-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

4.2: 4 h / 20 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; 10% Pt/activated carbon; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

methyl 2-bromo-2-(4-chlorophenyl)acetate

4-nitro-1H-indoIe

1-fluoro-2-iodoethane

methyl {4-[(tert-butoxycarbonyl)amino]-1H-indol-1-yl}(4-chlorophenyl)acetate

Downstream raw materials:

methyl 2-(4-amino-1H-indol-1-yl)-2-(4-chlorophenyl)-4-fluorobutanoate

methyl 2-(4-chlorophenyl)-4-fluoro-2-(4-(methylsulfonamido)-1H-indol-1-yl)butanoate

Refernces